Aiming at the problems of automatic control of camera load parameters and real-time tracking of the flight path in the remote sensing photography of Unmanned Aerial Vehicle (UAV), this paper presented a design scheme which could complete camera load control and aerial control automatically. First, the information of real-time geographic location and environment forecasting could be acquired in the system according to experimental requirements, and the parameter encoding was completed based on the table of camera control parameters; second, the custom protocol instruction set was sent to hardware control circuits through the communication port to complete the set of camera load parameters, and photography could be completed. Meanwhile, the geographic coordinate information of real-time flight path was recorded by the route planning software. The system can combine hardware control platform with software data processing, to achieve collaborative control. The UAV experiment results show that compared with the mode of single parameter aerial control, the proposed system in this paper can automatically control camera parameters and track real-time flight path according to different photography conditions and photography scenes.